Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-phenyl benzamides as a starting point for hit-to-lead medicinal chemistry. Eighty two analogues were...

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Publicado en:Bioorg Med Chem
Autores principales: Buchynskyy, Andriy, Gillespie, J. Robert, Hulverson, Matthew A., McQueen, Joshua, Creason, Sharon A., Ranade, Ranae M., Duster, Nicole A., Gelb, Michael H., Buckner, Frederick S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419589/
https://ncbi.nlm.nih.gov/pubmed/28187957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.11.019
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