New Class of Antitrypanosomal Agents Based on Imidazopyridines

[Image: see text] The present work describes the synthesis of 22 new imidazopyridine analogues arising from medicinal chemistry optimization at different sites on the molecule. Seven and 12 compounds exhibited an in vitro EC(50) ≤ 1 μM against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T....

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Publicat a:ACS Med Chem Lett
Autors principals: Silva, Daniel G., Gillespie, J. Robert, Ranade, Ranae M., Herbst, Zackary M., Nguyen, Uyen T. T., Buckner, Frederick S., Montanari, Carlos A., Gelb, Michael H.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512129/
https://ncbi.nlm.nih.gov/pubmed/28740614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00202
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