Triazolopyrimidines and Imidazopyridines: Structure–Activity Relationships and in Vivo Efficacy for Trypanosomiasis

[Image: see text] Better therapeutics are greatly needed to treat patients infected with trypanosomatid parasites such as Trypanosoma cruzi or Trypanosoma brucei. This report describes 28 new imidazopyridines and triazolopyrimidines with potent and selective antitrypanosomal activity. Drug-like prop...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Nagendar, Pendem, Gillespie, J. Robert, Herbst, Zackary M., Ranade, Ranae M., Molasky, Nora M. R., Faghih, Omeed, Turner, Rachael M., Gelb, Michael H., Buckner, Frederick S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2018
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331164/
https://ncbi.nlm.nih.gov/pubmed/30655955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00498
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