Triazolopyrimidines and Imidazopyridines: Structure–Activity Relationships and in Vivo Efficacy for Trypanosomiasis

[Image: see text] Better therapeutics are greatly needed to treat patients infected with trypanosomatid parasites such as Trypanosoma cruzi or Trypanosoma brucei. This report describes 28 new imidazopyridines and triazolopyrimidines with potent and selective antitrypanosomal activity. Drug-like prop...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Nagendar, Pendem, Gillespie, J. Robert, Herbst, Zackary M., Ranade, Ranae M., Molasky, Nora M. R., Faghih, Omeed, Turner, Rachael M., Gelb, Michael H., Buckner, Frederick S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331164/
https://ncbi.nlm.nih.gov/pubmed/30655955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00498
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