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Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach
The work began with the screening of a library of 700,000 small molecules for inhibitors of Trypanosoma brucei growth (a phenotypic screen). The resulting set of 1035 hit compounds was reviewed by a team of medicinal chemists, leading to the nomination of 17 chemically distinct scaffolds for further...
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| Publicado no: | Trop Med Infect Dis |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7157241/ https://ncbi.nlm.nih.gov/pubmed/32033395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/tropicalmed5010023 |
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