Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

[Image: see text] Malaria is one of the leading causes of severe infectious disease worldwide, yet our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance. We previously reported identification of a new class of triazolopyrimidine...

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Bibliografische gegevens
Hoofdauteurs: Gujjar, Ramesh, Mazouni, Farah El, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy, Floyd, David M., Matthews, David, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124361/
https://ncbi.nlm.nih.gov/pubmed/21517059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200265b
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