Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from five of these chemical classes have been developed further through different combinations of prelimi...

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Autores principales: Holloway, Georgina A., Charman, William N., Fairlamb, Alan H., Brun, Reto, Kaiser, Marcel, Kostewicz, Edmund, Novello, Patrizia M., Parisot, John P., Richardson, John, Street, Ian P., Watson, Keith G., Baell, Jonathan B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704697/
https://ncbi.nlm.nih.gov/pubmed/19364854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01568-08
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