Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from five of these chemical classes have been developed further through different combinations of prelimi...

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Autori principali: Holloway, Georgina A., Charman, William N., Fairlamb, Alan H., Brun, Reto, Kaiser, Marcel, Kostewicz, Edmund, Novello, Patrizia M., Parisot, John P., Richardson, John, Street, Ian P., Watson, Keith G., Baell, Jonathan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704697/
https://ncbi.nlm.nih.gov/pubmed/19364854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01568-08
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