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High-Throughput Screening Affords Novel and Selective Trypanothione Reductase Inhibitors with Anti-Trypanosomal Activity

Trypanothione reductase (TR), an enzyme that buffers oxidative stress in trypanosomatid parasites, was screened against commercial libraries containing approximately 134,500 compounds. After secondary screening, four chemotypes were identified as screening positives with selectivity for TR over huma...

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Hlavní autoři: Martyn, Derek C., Jones, Deuan C., Fairlamb, Alan H., Clardy, Jon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428910/
https://ncbi.nlm.nih.gov/pubmed/17197182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.12.016
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