Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely re...

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Detalhes bibliográficos
Main Authors: Holloway, Georgina A., Baell, Jonathan B., Fairlamb, Alan H., Novello, Patrizia M., Parisot, John P., Richardson, John, Watson, Keith G., Street, Ian P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428904/
https://ncbi.nlm.nih.gov/pubmed/17194585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.11.090
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