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Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis
Trypanothione reductase (TryR) is a key validated enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes and leishmania parasites. This system is absent in humans, being replaced with glutathione and glutathione reductase, and as such offers a target for selective inhibition....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929371/ https://ncbi.nlm.nih.gov/pubmed/19557801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900097 |
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