Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

Trypanothione reductase (TryR) is a key validated enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes and leishmania parasites. This system is absent in humans, being replaced with glutathione and glutathione reductase, and as such offers a target for selective inhibition....

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Main Authors: Richardson, John L, Nett, Isabelle R E, Jones, Deuan C, Abdille, Mohamed H, Gilbert, Ian H, Fairlamb, Alan H
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929371/
https://ncbi.nlm.nih.gov/pubmed/19557801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900097
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