Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites. The lead compound BTCP (1, 1-(1-benzo[b]thiophen-2-yl-cyclohexyl) piperidine) was found to be a competitive inhibitor of...

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Bibliografiset tiedot
Päätekijät: Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: WILEY-VCH Verlag 2009
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Full Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929374/
https://ncbi.nlm.nih.gov/pubmed/19557802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900098
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