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A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport

PURPOSE: To establish a lymph-cannulated mouse model, and use the model to investigate the impact of lipid dose on exogenous and endogenous lipid recruitment, and drug transport, into the lymph of males versus females. Finally, lymphatic transport and drug absorption in the mouse were compared to ot...

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Bibliografiske detaljer
Main Authors: Trevaskis, Natalie L., Caliph, Suzanne M., Nguyen, Gary, Tso, Patrick, Charman, William N., Porter, Christopher J. H.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136478/
https://ncbi.nlm.nih.gov/pubmed/23430484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1000-0
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