An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine

The potential inhibitory effects of 3 excipients (polyethylene glycol [PEG] 400, Pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate [TPGS]) on the P-glycoprotein (P-gp)-mediated efflux of digoxin (DIG) and cytochrome P450 3A (CYP3A)-mediated metabolism of verapamil (VRP) h...

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Autori principali: Johnson, Brendan M., Charman, William N., Porter, Christopher J. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751329/
https://ncbi.nlm.nih.gov/pubmed/12646011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps040440
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