Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Por Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Publicado em 2012

High-Throughput Screening Affords Novel and Selective Trypanothione Reductase Inhibitors with Anti-Trypanosomal Activity

Por Martyn, Derek C., Jones, Deuan C., Fairlamb, Alan H., Clardy, Jon
Publicado em 2006

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

Por Nguyen, Suong, Jones, Deuan C., Wyllie, Susan, Fairlamb, Alan H., Phillips, Margaret A.
Publicado em 2013

Trypanosoma brucei UDP-Glucose:Glycoprotein Glucosyltransferase Has Unusual Substrate Specificity and Protects the Parasite from Stress

Por Izquierdo, Luis, Atrih, Abdel, Rodrigues, Joao A., Jones, Deuan C., Ferguson, Michael A. J.
Publicado em 2009

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi()

Por Jones, Deuan C., Ariza, Antonio, Chow, Wing-Huen A., Oza, Sandra L., Fairlamb, Alan H.
Publicado em 2010

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Por Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Publicado em 2010

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

Por Walton, Jeffrey G A, Jones, Deuan C, Kiuru, Paula, Durie, Alastair J, Westwood, Nicholas J, Fairlamb, Alan H
Publicado em 2011

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

Por Richardson, John L, Nett, Isabelle R E, Jones, Deuan C, Abdille, Mohamed H, Gilbert, Ian H, Fairlamb, Alan H
Publicado em 2009

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

Por Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Publicado no PLoS Negl Trop Dis (2015)

Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

Por Perez-Pineiro, Rolando, Burgos, Asdrubal, Jones, Deuan C., Andrew, Lena C., Rodriguez, Hortensia, Suarez, Margarita, Fairlamb, Alan H., Wishart, David S.
Publicado em 2009

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Por Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Publicado em 2009

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

Por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado em 2011

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado em 2009