Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for T. brucei in vivo. To identify novel inhibitors of TbTryS we screened our in-house d...

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Main Authors: Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320663/
https://ncbi.nlm.nih.gov/pubmed/22162199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100420
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