Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we describe the development and optimisation of a novel series of PTR1 inhibitors, based on benzo[d]imidazol-2-amine derivatives. Data are reporte...

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Detalhes bibliográficos
Main Authors: Spinks, Daniel, Ong, Han B, Mpamhanga, Chidochangu P, Shanks, Emma J, Robinson, David A, Collie, Iain T, Read, Kevin D, Frearson, Julie A, Wyatt, Paul G, Brenk, Ruth, Fairlamb, Alan H, Gilbert, Ian H
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
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Full Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047710/
https://ncbi.nlm.nih.gov/pubmed/21275054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000450
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