One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

[Image: see text] The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for fragments inhibiting PTR1 was carried out. Two novel chemical series were identified containing aminobenzothiazole and aminobenzi...

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Main Authors: Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2009
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966039/
https://ncbi.nlm.nih.gov/pubmed/19527033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900414x
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