Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

The protozoan Trypanosoma brucei has a functional pteridine reductase (TbPTR1), an NADPH-dependent short-chain reductase that participates in the salvage of pterins, which are essential for parasite growth. PTR1 displays broad-spectrum activity with pterins and folates, provides a metabolic bypass f...

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Detalhes bibliográficos
Main Authors: Dawson, Alice, Gibellini, Federica, Sienkiewicz, Natasha, Tulloch, Lindsay B, Fyfe, Paul K, McLuskey, Karen, Fairlamb, Alan H, Hunter, William N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618733/
https://ncbi.nlm.nih.gov/pubmed/16968221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2006.05332.x
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