Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. To identify inhibitors of Leishmania major and Trypanosoma cruzi PTR1, we combined a rapid-screening strategy using a folate-based library with struc...

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Détails bibliographiques
Auteurs principaux: Cavazzuti, Antonio, Paglietti, Giuseppe, Hunter, William N., Gamarro, Francisco, Piras, Sandra, Loriga, Mario, Allecca, Sergio, Corona, Paola, McLuskey, Karen, Tulloch, Lindsay, Gibellini, Federica, Ferrari, Stefania, Costi, Maria Paola
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234164/
https://ncbi.nlm.nih.gov/pubmed/18245389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704384105
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