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Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1
[Image: see text] The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a cand...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2014
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136963/ https://ncbi.nlm.nih.gov/pubmed/25007262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500483b |
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