Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

[Image: see text] The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a cand...

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Detalhes bibliográficos
Main Authors: Khalaf, Abedawn I., Huggan, Judith K., Suckling, Colin J., Gibson, Colin L., Stewart, Kirsten, Giordani, Federica, Barrett, Michael P., Wong, Pui Ee, Barrack, Keri L., Hunter, William N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136963/
https://ncbi.nlm.nih.gov/pubmed/25007262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500483b
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