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An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics
A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treat...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Editions Scientifiques Elsevier
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4872591/ https://ncbi.nlm.nih.gov/pubmed/27060763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.03.064 |
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