An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treat...

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Publicat a:Eur J Med Chem
Autors principals: Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Format: Artigo
Idioma:Inglês
Publicat: Editions Scientifiques Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872591/
https://ncbi.nlm.nih.gov/pubmed/27060763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.03.064
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