Ranking Ligand Affinity for the DNA Minor Groove by Experiment and Simulation

[Image: see text] The structural and thermodynamic basis for the strength and selectivity of the interactions of minor groove binders (MGBs) with DNA is not fully understood. In 2003, we reported the first example of a thiazole-containing MGB that bound in a phase-shifted pattern that spanned six ba...

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Detalhes bibliográficos
Main Authors: Wittayanarakul, Kitiyaporn, Anthony, Nahoum G., Treesuwan, Witcha, Hannongbua, Supa, Alniss, Hasan, Khalaf, Abedawn I., Suckling, Colin J., Parkinson, John A, Mackay, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007966/
https://ncbi.nlm.nih.gov/pubmed/24900221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100047n
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