An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treat...

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Detaylı Bibliyografya
Yayımlandı:Eur J Med Chem
Asıl Yazarlar: Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Editions Scientifiques Elsevier 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872591/
https://ncbi.nlm.nih.gov/pubmed/27060763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.03.064
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