An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treat...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Eur J Med Chem
Главные авторы: Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Формат: Artigo
Язык:Inglês
Опубликовано: Editions Scientifiques Elsevier 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872591/
https://ncbi.nlm.nih.gov/pubmed/27060763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.03.064
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы