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High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target

Pteridine reductase (PTR1) is a potential target for drug development against parasitic Trypanosoma and Leishmania species. These protozoa cause serious diseases for which current therapies are inadequate. High-resolution structures have been determined, using data between 1.6 and 1.1 Å resolution,...

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Detaylı Bibliyografya
Asıl Yazarlar: Dawson, Alice, Tulloch, Lindsay B., Barrack, Keri L., Hunter, William N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655514/
https://ncbi.nlm.nih.gov/pubmed/21123874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910040886
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