Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent quinonoid dihydropteridine reductase (QDPR) to salvage and maintain intracellular pools of tetrahydrobiopterin (H(4)B). However, the African trypanosome lacks a credible candidat...

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Detalhes bibliográficos
Main Authors: Ong, Han B., Sienkiewicz, Natasha, Wyllie, Susan, Fairlamb, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060496/
https://ncbi.nlm.nih.gov/pubmed/21239486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209593
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