Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

[Image: see text] Pteridine reductase (PTR1) is a target for drug development against Trypanosoma and Leishmania species, parasites that cause serious tropical diseases and for which therapies are inadequate. We adopted a structure-based approach to the design of novel PTR1 inhibitors based on three...

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Detalhes bibliográficos
Main Authors: Tulloch, Lindsay B., Martini, Viviane P., Iulek, Jorge, Huggan, Judith K., Lee, Jeong Hwan, Gibson, Colin L., Smith, Terry K., Suckling, Colin J., Hunter, William N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2009
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804273/
https://ncbi.nlm.nih.gov/pubmed/19916554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901059x
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