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Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases
[Image: see text] Pteridine reductase (PTR1) is a target for drug development against Trypanosoma and Leishmania species, parasites that cause serious tropical diseases and for which therapies are inadequate. We adopted a structure-based approach to the design of novel PTR1 inhibitors based on three...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical Society
2009
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804273/ https://ncbi.nlm.nih.gov/pubmed/19916554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901059x |
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