One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

[Image: see text] The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for fragments inhibiting PTR1 was carried out. Two novel chemical series were identified containing aminobenzothiazole and aminobenzi...

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Bibliografiske detaljer
Main Authors: Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2009
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966039/
https://ncbi.nlm.nih.gov/pubmed/19527033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900414x
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