2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, affects 8–10 million people across the Latin American population and is responsible for around 12,500 deaths per annum. The current frontline treatments, benznidazole and nifurtimox, are associated with side effects and lack effica...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Thomas, Michael G., De Rycker, Manu, Cotillo Torrejon, Ignacio, Thomas, John, Riley, Jennifer, Spinks, Daniel, Read, Kevin D., Miles, Tim J., Gilbert, Ian H., Wyatt, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970618/
https://ncbi.nlm.nih.gov/pubmed/30104093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.08.005
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