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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
A resazurin-based cell viability assay was developed for phenotypic screening of the LOPAC 1280 ‘library of pharmacologically active compounds’ against bloodstream forms of Trypanosoma brucei in vitro identifying 33 compounds with EC(50) values <1 μM. Counter-screening vs. normal diploid human fi...
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| Hoofdauteurs: | , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier Science
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025325/ https://ncbi.nlm.nih.gov/pubmed/20696141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.038 |
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