A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

[Image: see text] Crystallography has guided the hybridization of two series of Trypanosoma bruceiN-myristoyltransferase (NMT) inhibitors, leading to a novel highly selective series. The effect of combining the selectivity enhancing elements from two pharmacophores is shown to be additive and has le...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2018
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167002/
https://ncbi.nlm.nih.gov/pubmed/30207721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00884
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