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The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

The novel nitroimidazopyran agent (S)-PA-824 has potent antibacterial activity against Mycobacterium tuberculosis in vitro and in vivo and is currently in phase II clinical trials for tuberculosis (TB). In contrast to M. tuberculosis, where (R)-PA-824 is inactive, we report here that both enantiomer...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Patterson, Stephen, Wyllie, Susan, Stojanovski, Laste, Perry, Meghan R., Simeons, Frederick R. C., Norval, Suzanne, Osuna-Cabello, Maria, De Rycker, Manu, Read, Kevin D., Fairlamb, Alan H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811480/
https://ncbi.nlm.nih.gov/pubmed/23856774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00722-13
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