Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Visceral leishmaniasis (VL) causes significant mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidin...

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Publicado no:Nature
Main Authors: Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick, Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402543/
https://ncbi.nlm.nih.gov/pubmed/30046105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0356-z
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