Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target I...

Por Wilson, Colin R., Gessner, Richard K., Moosa, Atica, Seldon, Ronnett, Warner, Digby F., Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B., Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M., Barry, Clifton E., Sirgel, Frederick A., van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J., Ghorpade, Sandeep R., Chibale, Kelly
Publicado no J Med Chem (2017)

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Por Park, Yumi, Pacitto, Angela, Bayliss, Tracy, Cleghorn, Laura A. T., Wang, Zhe, Hartman, Travis, Arora, Kriti, Ioerger, Thomas R., Sacchettini, Jim, Rizzi, Menico, Donini, Stefano, Blundell, Tom L., Ascher, David B., Rhee, Kyu, Breda, Ardala, Zhou, Nian, Dartois, Veronique, Jonnala, Surendranadha Reddy, Via, Laura E., Mizrahi, Valerie, Epemolu, Ola, Stojanovski, Laste, Simeons, Fred, Osuna-Cabello, Maria, Ellis, Lucy, MacKenzie, Claire J., Smith, Alasdair R. C., Davis, Susan H., Murugesan, Dinakaran, Buchanan, Kirsteen I., Turner, Penelope A., Huggett, Margaret, Zuccotto, Fabio, Rebollo-Lopez, Maria Jose, Lafuente-Monasterio, Maria Jose, Sanz, Olalla, Santos Diaz, Gracia, Lelièvre, Joël, Ballell, Lluis, Selenski, Carolyn, Axtman, Matthew, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Bösche, Markus, Drewes, Gerard, Freiberg, Gail M., Kurnick, Matthew D., Srikumaran, Myron, Kempf, Dale J., Green, Simon R., Ray, Peter C., Read, Kevin, Wyatt, Paul, Barry, Clifton E, Boshoff, Helena I.
Publicado no ACS Infect Dis (2016)