Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

מאת Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
יצא לאור 2009

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Le...

מאת Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A T, Ojo, Kayode K, Van Voorhis, Wesley C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
יצא לאור 2013

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

מאת Cleghorn, Laura A T, Woodland, Andrew, Collie, Iain T, Torrie, Leah S, Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G, Mottram, Jeremy C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
יצא לאור 2011

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

מאת Smith, Victoria C, Cleghorn, Laura A T, Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T, Yi Mok, N, Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H, Frearson, Julie A, Read, Kevin D, Gilbert, Ian H, Wyatt, Paul G
יצא לאור 2011

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

מאת Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
הוצא לאור ב J Med Chem (2015)

Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis

מאת Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
הוצא לאור ב Antimicrob Agents Chemother (2014)

Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis”

מאת Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
הוצא לאור ב Antimicrob Agents Chemother (2017)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

מאת Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
הוצא לאור ב ChemMedChem (2015)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

מאת Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
יצא לאור 2011

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

מאת Cleghorn, Laura A. T., Ray, Peter C., Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D., Green, Simon R., Hipskind, Phil, Parish, Tanya, Wyatt, Paul G.
הוצא לאור ב J Med Chem (2018)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

מאת Frearson, Julie A., Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A.T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Hallyburton, Irene, Mpamhanga, Chidochangu P., Brannigan, James A., Wilkinson, Anthony J., Hodgkinson, Michael, Hui, Raymond, Qiu, Wei, Raimi, Olawale G., van Aalten, Daan M. F., Brenk, Ruth, Gilbert, Ian H., Read, Kevin D., Fairlamb, Alan H., Ferguson, Michael A. J., Smith, Deborah F., Wyatt, Paul G.
יצא לאור 2010

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

מאת Ray, Peter C., Huggett, Margaret, Turner, Penelope A., Taylor, Malcolm, Cleghorn, Laura A. T., Early, Julie, Kumar, Anuradha, Bonnett, Shilah A., Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L., Davis, Susan H., Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A., Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T., Lenaerts, Anne J., Freiberg, Gail, Kempf, Dale J., Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Read, Kevin D., Green, Simon R., Wyatt, Paul G., Parish, Tanya
הוצא לאור ב ACS Omega (2021)

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

מאת Park, Yumi, Pacitto, Angela, Bayliss, Tracy, Cleghorn, Laura A. T., Wang, Zhe, Hartman, Travis, Arora, Kriti, Ioerger, Thomas R., Sacchettini, Jim, Rizzi, Menico, Donini, Stefano, Blundell, Tom L., Ascher, David B., Rhee, Kyu, Breda, Ardala, Zhou, Nian, Dartois, Veronique, Jonnala, Surendranadha Reddy, Via, Laura E., Mizrahi, Valerie, Epemolu, Ola, Stojanovski, Laste, Simeons, Fred, Osuna-Cabello, Maria, Ellis, Lucy, MacKenzie, Claire J., Smith, Alasdair R. C., Davis, Susan H., Murugesan, Dinakaran, Buchanan, Kirsteen I., Turner, Penelope A., Huggett, Margaret, Zuccotto, Fabio, Rebollo-Lopez, Maria Jose, Lafuente-Monasterio, Maria Jose, Sanz, Olalla, Santos Diaz, Gracia, Lelièvre, Joël, Ballell, Lluis, Selenski, Carolyn, Axtman, Matthew, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Bösche, Markus, Drewes, Gerard, Freiberg, Gail M., Kurnick, Matthew D., Srikumaran, Myron, Kempf, Dale J., Green, Simon R., Ray, Peter C., Read, Kevin, Wyatt, Paul, Barry, Clifton E, Boshoff, Helena I.
הוצא לאור ב ACS Infect Dis (2016)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

מאת Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Albrecht, Sébastian, Álvarez-Pedraglio, Ana Isabel, Boesche, Markus, Brand, Stephen, Campbell, Lorna, Cantizani-Perez, Juan, Cleghorn, Laura A.T., Copley, Royston C.B., Crouch, Sabrinia D., Daugan, Alain, Drewes, Gerard, Ferrer, Santiago, Ghidelli-Disse, Sonja, Gonzalez, Silvia, Gresham, Stephanie L., Hill, Alan P., Hindley, Sean J., Lowe, Rhiannon M., MacKenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Miguel-Siles, Juan, Nguyen, Van Loc, Norval, Suzanne, Osuna-Cabello, Maria, Woodland, Andrew, Patterson, Stephen, Pena, Imanol, Quesada-Campos, Maria Teresa, Reid, Iain H., Revill, Charlotte, Riley, Jennifer, Ruiz-Gomez, Jose Ramon, Shishikura, Yoko, Simeons, Frederick R.C., Smith, Alasdair, Smith, Victoria C., Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Underwood, Tim, Gray, David W., Fiandor, Jose M., Gilbert, Ian H., Wyatt, Paul G., Read, Kevin D., Miles, Timothy J.
הוצא לאור ב J Med Chem (2018)