Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado em 2009

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Le...

Por Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A T, Ojo, Kayode K, Van Voorhis, Wesley C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2013

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Por Cleghorn, Laura A T, Woodland, Andrew, Collie, Iain T, Torrie, Leah S, Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G, Mottram, Jeremy C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2011

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Por Smith, Victoria C, Cleghorn, Laura A T, Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T, Yi Mok, N, Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H, Frearson, Julie A, Read, Kevin D, Gilbert, Ian H, Wyatt, Paul G
Publicado em 2011

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Por Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Publicado no J Med Chem (2015)

Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis

Por Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
Publicado no Antimicrob Agents Chemother (2014)

Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis”

Por Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I.
Publicado no Antimicrob Agents Chemother (2017)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Por Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A T, Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A, Gray, David W, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H
Publicado no ChemMedChem (2015)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Por Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicado em 2011

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Por Cleghorn, Laura A. T., Ray, Peter C., Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D., Green, Simon R., Hipskind, Phil, Parish, Tanya, Wyatt, Paul G.
Publicado no J Med Chem (2018)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Por Frearson, Julie A., Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A.T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Hallyburton, Irene, Mpamhanga, Chidochangu P., Brannigan, James A., Wilkinson, Anthony J., Hodgkinson, Michael, Hui, Raymond, Qiu, Wei, Raimi, Olawale G., van Aalten, Daan M. F., Brenk, Ruth, Gilbert, Ian H., Read, Kevin D., Fairlamb, Alan H., Ferguson, Michael A. J., Smith, Deborah F., Wyatt, Paul G.
Publicado em 2010

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

Por Ray, Peter C., Huggett, Margaret, Turner, Penelope A., Taylor, Malcolm, Cleghorn, Laura A. T., Early, Julie, Kumar, Anuradha, Bonnett, Shilah A., Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L., Davis, Susan H., Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A., Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T., Lenaerts, Anne J., Freiberg, Gail, Kempf, Dale J., Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Read, Kevin D., Green, Simon R., Wyatt, Paul G., Parish, Tanya
Publicado no ACS Omega (2021)

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Por Park, Yumi, Pacitto, Angela, Bayliss, Tracy, Cleghorn, Laura A. T., Wang, Zhe, Hartman, Travis, Arora, Kriti, Ioerger, Thomas R., Sacchettini, Jim, Rizzi, Menico, Donini, Stefano, Blundell, Tom L., Ascher, David B., Rhee, Kyu, Breda, Ardala, Zhou, Nian, Dartois, Veronique, Jonnala, Surendranadha Reddy, Via, Laura E., Mizrahi, Valerie, Epemolu, Ola, Stojanovski, Laste, Simeons, Fred, Osuna-Cabello, Maria, Ellis, Lucy, MacKenzie, Claire J., Smith, Alasdair R. C., Davis, Susan H., Murugesan, Dinakaran, Buchanan, Kirsteen I., Turner, Penelope A., Huggett, Margaret, Zuccotto, Fabio, Rebollo-Lopez, Maria Jose, Lafuente-Monasterio, Maria Jose, Sanz, Olalla, Santos Diaz, Gracia, Lelièvre, Joël, Ballell, Lluis, Selenski, Carolyn, Axtman, Matthew, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Bösche, Markus, Drewes, Gerard, Freiberg, Gail M., Kurnick, Matthew D., Srikumaran, Myron, Kempf, Dale J., Green, Simon R., Ray, Peter C., Read, Kevin, Wyatt, Paul, Barry, Clifton E, Boshoff, Helena I.
Publicado no ACS Infect Dis (2016)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Por Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Albrecht, Sébastian, Álvarez-Pedraglio, Ana Isabel, Boesche, Markus, Brand, Stephen, Campbell, Lorna, Cantizani-Perez, Juan, Cleghorn, Laura A.T., Copley, Royston C.B., Crouch, Sabrinia D., Daugan, Alain, Drewes, Gerard, Ferrer, Santiago, Ghidelli-Disse, Sonja, Gonzalez, Silvia, Gresham, Stephanie L., Hill, Alan P., Hindley, Sean J., Lowe, Rhiannon M., MacKenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Miguel-Siles, Juan, Nguyen, Van Loc, Norval, Suzanne, Osuna-Cabello, Maria, Woodland, Andrew, Patterson, Stephen, Pena, Imanol, Quesada-Campos, Maria Teresa, Reid, Iain H., Revill, Charlotte, Riley, Jennifer, Ruiz-Gomez, Jose Ramon, Shishikura, Yoko, Simeons, Frederick R.C., Smith, Alasdair, Smith, Victoria C., Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Underwood, Tim, Gray, David W., Fiandor, Jose M., Gilbert, Ian H., Wyatt, Paul G., Read, Kevin D., Miles, Timothy J.
Publicado no J Med Chem (2018)