Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

অনুযায়ী Norcliffe, Jennifer L., Mina, John G., Alvarez, Emilio, Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo, Valle, Silva Gonzalez-Del, Marco, Maria, Fiandor, José M., Martin, Julio J., Steel, Patrick G., Denny, Paul W.
প্রকাশিত Sci Rep (2018)

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

অনুযায়ী Peña, Imanol, Pilar Manzano, M., Cantizani, Juan, Kessler, Albane, Alonso-Padilla, Julio, Bardera, Ana I., Alvarez, Emilio, Colmenarejo, Gonzalo, Cotillo, Ignacio, Roquero, Irene, de Dios-Anton, Francisco, Barroso, Vanessa, Rodriguez, Ana, Gray, David W., Navarro, Miguel, Kumar, Vinod, Sherstnev, Alexander, Drewry, David H., Brown, James R., Fiandor, Jose M., Julio Martin, J.
প্রকাশিত Sci Rep (2015)

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

অনুযায়ী Thomas, Michael G., De Rycker, Manu, Wall, Richard J., Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Wyllie, Susan, Read, Kevin D., Miles, Timothy J., Gilbert, Ian H.
প্রকাশিত J Med Chem (2020)

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

অনুযায়ী Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G., Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M., Martin, Julio, Wyatt, Paul G., Miles, Timothy J., Read, Kevin D., Marco, Maria, Gilbert, Ian H.
প্রকাশিত J Med Chem (2021)

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

অনুযায়ী Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.
প্রকাশিত RSC Med Chem (2020)

Short-course combination treatment for experimental chronic Chagas disease

অনুযায়ী González, Silvia, Wall, Richard J., Thomas, John, Braillard, Stephanie, Brunori, Gino, Díaz, Isabel Camino, Cantizani, Juan, Carvalho, Sandra, Castañeda Casado, Pablo, Chatelain, Eric, Cotillo, Ignacio, Fiandor, Jose M., Francisco, Amanda Fortes, Grimsditch, David, Keenan, Martine, Kelly, John M., Kessler, Albane, Luise, Chiara, Lyon, Jon J., MacLean, Lorna, Marco, Maria, Martin, J. Julio, Martinez, Maria S., Paterson, Christy, Read, Kevin D., Santos-Villarejo, Angel, Zuccotto, Fabio, Wyllie, Susan, Miles, Tim J., De Rycker, Manu
প্রকাশিত Sci Transl Med (2023)

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

অনুযায়ী Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick, Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
প্রকাশিত Nature (2018)

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

অনুযায়ী Brand, Stephen, Ko, Eun Jung, Viayna, Elisabet, Thompson, Stephen, Spinks, Daniel, Thomas, Michael, Sandberg, Lars, Francisco, Amanda F., Jayawardhana, Shiromani, Smith, Victoria C., Jansen, Chimed, De Rycker, Manu, Thomas, John, MacLean, Lorna, Osuna-Cabello, Maria, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., Epemolu, Ola, Shishikura, Yoko, Crouch, Sabrinia D., Bakshi, Tania S., Nixon, Christopher J., Reid, Iain H., Hill, Alan P., Underwood, Tim Z., Hindley, Sean J., Robinson, Sharon A., Kelly, John M., Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
প্রকাশিত J Med Chem (2017)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

অনুযায়ী Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna Gaza, Elisabet, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.
প্রকাশিত Proc Natl Acad Sci U S A (2019)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

অনুযায়ী Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Albrecht, Sébastian, Álvarez-Pedraglio, Ana Isabel, Boesche, Markus, Brand, Stephen, Campbell, Lorna, Cantizani-Perez, Juan, Cleghorn, Laura A.T., Copley, Royston C.B., Crouch, Sabrinia D., Daugan, Alain, Drewes, Gerard, Ferrer, Santiago, Ghidelli-Disse, Sonja, Gonzalez, Silvia, Gresham, Stephanie L., Hill, Alan P., Hindley, Sean J., Lowe, Rhiannon M., MacKenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Miguel-Siles, Juan, Nguyen, Van Loc, Norval, Suzanne, Osuna-Cabello, Maria, Woodland, Andrew, Patterson, Stephen, Pena, Imanol, Quesada-Campos, Maria Teresa, Reid, Iain H., Revill, Charlotte, Riley, Jennifer, Ruiz-Gomez, Jose Ramon, Shishikura, Yoko, Simeons, Frederick R.C., Smith, Alasdair, Smith, Victoria C., Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Underwood, Tim, Gray, David W., Fiandor, Jose M., Gilbert, Ian H., Wyatt, Paul G., Read, Kevin D., Miles, Timothy J.
প্রকাশিত J Med Chem (2018)