The use of biophysical methods increases success in obtaining liganded crystal structures

Por Chung, Chun-wa
Publicado em 2007

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry

Por Bax, Ben, Chung, Chun-wa, Edge, Colin
Publicado no Acta Crystallogr D Struct Biol (2017)

Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin

Por Ryan, Ali J, Chung, Chun-wa, Curry, Stephen
Publicado em 2011

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin

Por Ryan, Ali J., Ghuman, Jamie, Zunszain, Patricia A., Chung, Chun-wa, Curry, Stephen
Publicado em 2011

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome

Por Schulz, Danae, Mugnier, Monica R., Paulsen, Eda-Margaret, Kim, Hee-Sook, Chung, Chun-wa W., Tough, David F., Rioja, Inmaculada, Prinjha, Rab K., Papavasiliou, F. Nina, Debler, Erik W.
Publicado no PLoS Biol (2015)

Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capa...

Por Walker, Adam, Chung, Chun-Wa, Neu, Margarete, Burman, Manish, Batuwangala, Thil, Jones, Gavin, Tang, Chi-Man, Steward, Michael, Mullin, Michael, Tournier, Nadia, Lewis, Alan, Korczynska, Justyna, Chung, Vicky, Catchpole, Ian
Publicado no J Biol Chem (2016)

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

Por Sullivan, Josefa M., Badimon, Ana, Schaefer, Uwe, Ayata, Pinar, Gray, James, Chung, Chun-wa, von Schimmelmann, Melanie, Zhang, Fan, Garton, Neil, Smithers, Nicholas, Lewis, Huw, Tarakhovsky, Alexander, Prinjha, Rab K., Schaefer, Anne
Publicado no J Exp Med (2015)

Correction: Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

Por Grimley, Rachel, Polyakova, Oxana, Vamathevan, Jessica, McKenary, Joanne, Hayes, Brian, Patel, Champa, Smith, Janet, Bridges, Angela, Fosberry, Andrew, Bhardwaja, Anshu, Mouzon, Bernadette, Chung, Chun-Wa, Barrett, Nathalie, Richmond, Nicola, Modha, Sundip, Solari, Roberto
Publicado em 2012

Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

Por Grimley, Rachel, Polyakova, Oxana, Vamathevan, Jessica, McKenary, Joanne, Hayes, Brian, Patel, Champa, Smith, Janet, Bridges, Angela, Fosberry, Andrew, Bhardwaja, Anshu, Mouzon, Bernadette, Chung, Chun-Wa, Barrett, Nathalie, Richmond, Nicola, Modha, Sundip, Solari, Roberto
Publicado em 2012

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Por Chen, Peiling, Chaikuad, Apirat, Bamborough, Paul, Bantscheff, Marcus, Bountra, Chas, Chung, Chun-wa, Fedorov, Oleg, Grandi, Paola, Jung, David, Lesniak, Robert, Lindon, Matthew, Müller, Susanne, Philpott, Martin, Prinjha, Rab, Rogers, Catherine, Selenski, Carolyn, Tallant, Cynthia, Werner, Thilo, Willson, Timothy M., Knapp, Stefan, Drewry, David H.
Publicado no J Med Chem (2015)

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Por Demont, Emmanuel H., Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D., Fallon, David, Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hussain, Jameed, Jones, Emma J., Le Gall, Armelle, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J.
Publicado no ACS Med Chem Lett (2014)

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Por Wyce, Anastasia, Ganji, Gopinath, Smitheman, Kimberly N., Chung, Chun-wa, Korenchuk, Susan, Bai, Yuchen, Barbash, Olena, Le, BaoChau, Craggs, Peter D., McCabe, Michael T., Kennedy-Wilson, Karen M., Sanchez, Lydia V., Gosmini, Romain L., Parr, Nigel, McHugh, Charles F., Dhanak, Dashyant, Prinjha, Rab K., Auger, Kurt R., Tummino, Peter J.
Publicado em 2013

Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors

Por Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora, Messer, Jeffrey A., Somers, Donald O., Ajakane, Myriam, Arico-Muendel, Christopher C., Beljean, Arthur, Belyanskaya, Svetlana L., Bingham, Ryan, Blazensky, Emily, Boullay, Anne-Benedicte, Boursier, Eric, Chai, Jing, Carter, Paul, Chung, Chun-Wa, Daugan, Alain, Ding, Yun, Herry, Kenny, Hobbs, Clare, Humphries, Eric, Kollmann, Christopher, Nguyen, Van Loc, Nicodeme, Edwige, Smith, Sarah E., Dodic, Nerina, Ancellin, Nicolas
Publicado no ACS Med Chem Lett (2016)

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Por Dawson, Mark A., Prinjha, Rab K., Dittman, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C, Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E, Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J.P, Kouzarides, Tony
Publicado em 2011

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

Por Bamborough, Paul, Barnett, Heather A., Becher, Isabelle, Bird, Mark J., Chung, Chun-wa, Craggs, Peter D., Demont, Emmanuel H., Diallo, Hawa, Fallon, David J., Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hooper-Greenhill, Edward, Jones, Emma J., Law, Robert P., Le Gall, Armelle, Lugo, David, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Sheppard, Robert J., Watson, Allan J. B., Watson, Robert J.
Publicado no ACS Med Chem Lett (2016)

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Por Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.
Publicado no Nature (2012)

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library

Por Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora S., Summerfield, Jennifer, Somers, Don, Messer, Jeffrey A., Satz, Alexander L., Ancellin, Nicolas, Arico-Muendel, Christopher C., (Sargent) Bedard, Katie L., Beljean, Arthur, Belyanskaya, Svetlana L., Bingham, Ryan, Smith, Sarah E., Boursier, Eric, Carter, Paul, Centrella, Paolo A., Clark, Matthew A., Chung, Chun-wa, Davie, Christopher P., Delorey, Jennifer L., Ding, Yun, Franklin, G. Joseph, Grady, LaShadric C., Herry, Kenny, Hobbs, Clare, Kollmann, Christopher S., Morgan, Barry A., (Pothier) Kaushansky, Laura J., Zhou, Quan
Publicado no ACS Med Chem Lett (2015)

Identification of KasA as the cellular target of an anti-tubercular scaffold

Por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado no Nat Commun (2016)

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Por Lewis, Huw D., Liddle, John, Coote, Jim E., Atkinson, Stephen J., Barker, Michael D., Bax, Benjamin, D., Bicker, Kevin L., Bingham, Ryan P., Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D., Davis, Rob P., Eberhard, Dirk, Joberty, Gerard, Lind, Kenneth E., Locke, Kelly, Maller, Claire, Martinod, Kimberly, Patten, Chris, Polyakova, Oxana, Rise, Cecil E., Rüdiger, Martin, Sheppard, Robert J., Slade, Daniel J., Thomas, Pamela, Thorpe, Jim, Yao, Gang, Drewes, Gerard, Wagner, Denisa D., Thompson, Paul R., Prinjha, Rab K., Wilson, David M.
Publicado no Nat Chem Biol (2015)