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Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library
[Image: see text] As a potential target for obesity, human BCATm was screened against more than 14 billion DNA encoded compounds of distinct scaffolds followed by off-DNA synthesis and activity confirmation. As a consequence, several series of BCATm inhibitors were discovered. One representative com...
שמור ב:
| הוצא לאור ב: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2015
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538436/ https://ncbi.nlm.nih.gov/pubmed/26288694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00179 |
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