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BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice
Endotoxin (LPS) and sepsis decrease mammalian target of rapamycin (mTOR) activity in skeletal muscle, thereby reducing protein synthesis. Our study tests the hypothesis that inhibition of branched-chain amino acid (BCAA) catabolism, which elevates circulating BCAA and stimulates mTOR, will blunt the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944428/ https://ncbi.nlm.nih.gov/pubmed/20554928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00297.2010 |
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