Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics

Por Hothersall, J. Daniel, Guo, Dong, Sarda, Sunil, Sheppard, Robert J., Chen, Hongming, Keur, Wesley, Waring, Michael J., IJzerman, Adriaan P., Hill, Stephen J., Dale, Ian L., Rawlins, Philip B.
Publicado no Mol Pharmacol (2017)

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Por Demont, Emmanuel H., Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D., Fallon, David, Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hussain, Jameed, Jones, Emma J., Le Gall, Armelle, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J.
Publicado no ACS Med Chem Lett (2014)

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

Por Bamborough, Paul, Barnett, Heather A., Becher, Isabelle, Bird, Mark J., Chung, Chun-wa, Craggs, Peter D., Demont, Emmanuel H., Diallo, Hawa, Fallon, David J., Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hooper-Greenhill, Edward, Jones, Emma J., Law, Robert P., Le Gall, Armelle, Lugo, David, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Sheppard, Robert J., Watson, Allan J. B., Watson, Robert J.
Publicado no ACS Med Chem Lett (2016)

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Por Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.
Publicado no Nature (2012)

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Por Lewis, Huw D., Liddle, John, Coote, Jim E., Atkinson, Stephen J., Barker, Michael D., Bax, Benjamin, D., Bicker, Kevin L., Bingham, Ryan P., Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D., Davis, Rob P., Eberhard, Dirk, Joberty, Gerard, Lind, Kenneth E., Locke, Kelly, Maller, Claire, Martinod, Kimberly, Patten, Chris, Polyakova, Oxana, Rise, Cecil E., Rüdiger, Martin, Sheppard, Robert J., Slade, Daniel J., Thomas, Pamela, Thorpe, Jim, Yao, Gang, Drewes, Gerard, Wagner, Denisa D., Thompson, Paul R., Prinjha, Rab K., Wilson, David M.
Publicado no Nat Chem Biol (2015)