1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

[Image: see text] The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure–activity relationship (SAR) of the first potent, selective series...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Demont, Emmanuel H., Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D., Fallon, David, Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hussain, Jameed, Jones, Emma J., Le Gall, Armelle, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233354/
https://ncbi.nlm.nih.gov/pubmed/25408830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002932
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados