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1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
[Image: see text] The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure–activity relationship (SAR) of the first potent, selective series...
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233354/ https://ncbi.nlm.nih.gov/pubmed/25408830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002932 |
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