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1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
[Image: see text] The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure–activity relationship (SAR) of the first potent, selective series...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Med Chem Lett |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2014
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233354/ https://ncbi.nlm.nih.gov/pubmed/25408830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002932 |
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