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Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics

The duration of action of adenosine A(2A) receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied using cAMP assays in recombinantly (CHO) and endoge...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharmacol
Asıl Yazarlar: Hothersall, J. Daniel, Guo, Dong, Sarda, Sunil, Sheppard, Robert J., Chen, Hongming, Keur, Wesley, Waring, Michael J., IJzerman, Adriaan P., Hill, Stephen J., Dale, Ian L., Rawlins, Philip B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198511/
https://ncbi.nlm.nih.gov/pubmed/27803241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.105551
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