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Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics
The duration of action of adenosine A(2A) receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied using cAMP assays in recombinantly (CHO) and endoge...
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Publicado en: | Mol Pharmacol |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5198511/ https://ncbi.nlm.nih.gov/pubmed/27803241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.105551 |
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