Flexible modulation of agonist efficacy at the human A(3 )adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000

BACKGROUND: A series of 1H-imidazo- [4,5-c]quinolin-4-amine derivatives, represented by LUF6000 (N-(3,4-dichloro-phenyl)-2-cyclohexyl-1H-imidazo [4,5-c]quinolin-4-amine), are allosteric modulators of the human A(3 )adenosine receptor (AR). Here we studied the modulation by LUF6000 of the maximum eff...

Full description

Saved in:
Bibliographic Details
Main Authors: Gao, Zhan-Guo, Ye, Kai, Göblyös, Anikó, IJzerman, Adriaan P, Jacobson, Kenneth A
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625337/
https://ncbi.nlm.nih.gov/pubmed/19077268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-8-20
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items