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Structure-Activity Relationships of new 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as Allosteric Enhancers of the A(3) Adenosine Receptor

1H-imidazo[4,5-c]quinolin-4-amine derivatives have been synthesized as allosteric modulators of the human A(3) adenosine receptor (AR). Structural modifications were made at the 4-amino and 2 positions. The compounds were tested in both binding and functional assays, and many were found to be allost...

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Detalhes bibliográficos
Main Authors: Göblyös, Anikó, Gao, Zhan-Guo, Brussee, Johannes, Connestari, Roberto, Santiago, Sabrina Neves, Ye, Kai, IJzerman, Adriaan P., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547348/
https://ncbi.nlm.nih.gov/pubmed/16722654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060086s
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