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Structure-Activity Relationships of new 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as Allosteric Enhancers of the A(3) Adenosine Receptor
1H-imidazo[4,5-c]quinolin-4-amine derivatives have been synthesized as allosteric modulators of the human A(3) adenosine receptor (AR). Structural modifications were made at the 4-amino and 2 positions. The compounds were tested in both binding and functional assays, and many were found to be allost...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547348/ https://ncbi.nlm.nih.gov/pubmed/16722654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060086s |
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