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The use of biophysical methods increases success in obtaining liganded crystal structures

In attempts to determine the crystal structure of small molecule–protein complexes, a common frustration is the absence of ligand binding once the protein structure has been solved. While the first structure, even with no ligand bound (apo), can be a cause for celebration, the solution of dozens of...

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Библиографические подробности
Главный автор: Chung, Chun-wa
Формат: Artigo
Язык:Inglês
Опубликовано: International Union of Crystallography 2007
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483471/
https://ncbi.nlm.nih.gov/pubmed/17164528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444906051869
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