Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression

Por Coiras, Mayte, López-Huertas, María Rosa, Rullas, Joaquín, Mittelbrunn, Maria, Alcamí, José
Publicado em 2007

X-ray-based virtual slicing of TB-infected lungs

Por Ortega-Gil, Ana, Vaquero, Juan José, Gonzalez-Arjona, Mario, Rullas, Joaquín, Muñoz-Barrutia, Arrate
Publicado no Sci Rep (2019)

The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

Por Chen, Chunli, Ortega, Fatima, Rullas, Joaquin, Alameda, Laura, Angulo-Barturen, Iñigo, Ferrer, Santiago, Simonsson, Ulrika SH
Publicado no J Pharmacokinet Pharmacodyn (2017)

TRAF Family Proteins Link PKR with NF-κB Activation

Por Gil, Jesús, García, Maria Angel, Gomez-Puertas, Paulino, Guerra, Susana, Rullas, Joaquín, Nakano, Hiroyasu, Alcamí, José, Esteban, Mariano
Publicado em 2004

Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis

Por Rullas, Joaquín, García, Juan Ignacio, Beltrán, Manuela, Cardona, Pere-Joan, Cáceres, Neus, García-Bustos, José Francisco, Angulo-Barturen, Iñigo
Publicado em 2010

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

Por Rullas, Joaquín, Dhar, Neeraj, McKinney, John D., García-Pérez, Adolfo, Lelievre, Joël, Diacon, Andreas H., Hugonnet, Jean-Emmanuel, Arthur, Michel, Angulo-Barturen, Iñigo, Barros-Aguirre, David, Ballell, Lluís
Publicado no Antimicrob Agents Chemother (2015)

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

Por Kumar, Anuradha, Guardia, Ana, Colmenarejo, Gonzalo, Pérez, Esther, Gonzalez, Ruben R., Torres, Pedro, Calvo, David, Gómez, Ruben M., Ortega, Fátima, Jiménez, Elena, Gabarro, Raquel C., Rullás, Joaquín, Ballell, Lluis, Sherman, David R.
Publicado no ACS Infect Dis (2015)

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

Por Abrahams, Katherine A., Cox, Jonathan A. G., Fütterer, Klaus, Rullas, Joaquín, Ortega-Muro, Fátima, Loman, Nicholas J., Moynihan, Patrick J., Pérez-Herrán, Esther, Jiménez, Elena, Esquivias, Jorge, Barros, David, Ballell, Lluís, Alemparte, Carlos, Besra, Gurdyal S.
Publicado no Sci Rep (2017)

Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis

Por Poce, Giovanna, Consalvi, Sara, Venditti, Giulia, Alfonso, Salvatore, Desideri, Nicoletta, Fernandez-Menendez, Raquel, Bates, Robert H., Ballell, Lluis, Barros Aguirre, David, Rullas, Joaquin, De Logu, Alessandro, Gardner, Michelle, Ioerger, Thomas R., Rubin, Eric J., Biava, Mariangela
Publicado no ACS Med Chem Lett (2019)

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

Por Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Mulet, Teresa, Rullas, Joaquín, Herreros, Esperanza, Ferrer, Santiago, Jiménez, Elena, Mendoza, Alfonso, Regadera, Javier, Rosenthal, Philip J., Bathurst, Ian, Pompliano, David L., Gómez de las Heras, Federico, Gargallo-Viola, Domingo
Publicado em 2008

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

Por Poce, Giovanna, Bates, Robert H., Alfonso, Salvatore, Cocozza, Martina, Porretta, Giulio Cesare, Ballell, Lluís, Rullas, Joaquin, Ortega, Fátima, De Logu, Alessandro, Agus, Emanuela, La Rosa, Valentina, Pasca, Maria Rosalia, De Rossi, Edda, Wae, Baojie, Franzblau, Scott G., Manetti, Fabrizio, Botta, Maurizio, Biava, Mariangela
Publicado em 2013

Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs

Por Blanco, Delia, Perez-Herran, Esther, Cacho, Mónica, Ballell, Lluís, Castro, Julia, González del Río, Rubén, Lavandera, José Luis, Remuiñán, Modesto J., Richards, Cindy, Rullas, Joaquin, Vázquez-Muñiz, María Jesús, Woldu, Ermias, Zapatero-González, María Cleofé, Angulo-Barturen, Iñigo, Mendoza, Alfonso, Barros, David
Publicado no Antimicrob Agents Chemother (2015)

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Por Cleghorn, Laura A. T., Ray, Peter C., Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D., Green, Simon R., Hipskind, Phil, Parish, Tanya, Wyatt, Paul G.
Publicado no J Med Chem (2018)

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tub...

Por Remuiñán, Modesto J., Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J., Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Minick, Douglas J., Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S., Ballell, Lluís, Cammack, Nicholas
Publicado em 2013

Identification of KasA as the cellular target of an anti-tubercular scaffold

Por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado no Nat Commun (2016)

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Por Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z., Easom, Eric E., Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L., Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G., Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J., O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B., Waters, M. Gerard, Ma, Zhenkun, Ioerger, Thomas R., Sacchettini, James C., Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J., Alley, M. R. K.
Publicado no Antimicrob Agents Chemother (2016)