Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical chemical properties and drug-like parameters of this class of compounds, a medicinal chemistry effort was undertaken. By selecting the optimal...

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Detalhes bibliográficos
Main Authors: Poce, Giovanna, Bates, Robert H., Alfonso, Salvatore, Cocozza, Martina, Porretta, Giulio Cesare, Ballell, Lluís, Rullas, Joaquin, Ortega, Fátima, De Logu, Alessandro, Agus, Emanuela, La Rosa, Valentina, Pasca, Maria Rosalia, De Rossi, Edda, Wae, Baojie, Franzblau, Scott G., Manetti, Fabrizio, Botta, Maurizio, Biava, Mariangela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578785/
https://ncbi.nlm.nih.gov/pubmed/23437287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056980
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